WebSep 12, 2024 · The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been considered functionally redundant, … WebAug 19, 2024 · RagC knock-in mice show partial insensitivity to nutrient withdrawal. To determine the impact of mutations in the nutrient sensing pathway on B cell function and FL development in a physiological ...
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WebPlasmid pRK5 Flag-RagC from Dr. David Sabatini's lab contains the insert RagC and is published in Mol Cell. 2024 Oct 17. pii: S1097-2765(17)30704-9. doi: 10.1016/j.molcel.2024.09.026. This plasmid is available through Addgene. smud low income eligibility
SIGNAL TRANSDUCTION Structural mechanism of a Rag …
WebNov 22, 2024 · The tumor suppressor folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) activating protein (GAP) activity toward the GTPase RagC. Concomitant with mTORC1 inactivation by starvation, FLCN relocalizes from the … WebFeb 15, 2024 · RagC/D Summaries Gene Model and Products Expression Data Alleles, Insertions, Transgenic Constructs, and Aberrations Variants Phenotypes Orthologs Paralogs Human Disease Associations Functional Complementation Data Interactions Pathways Genomic Location and Detailed Mapping Data Stocks and Reagents Other Information WebSep 12, 2024 · The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been considered functionally redundant, but two studies now show that each... smud low-income application