Web14 de abr. de 2024 · In the IMPROVE-IT trial, researchers showed adding ezetimibe to moderate-intensity statins vs. moderate intensity statin alone in ASCVD patients resulted in lower LDL cholesterol levels and reduced ASCVD events, especially in those older than age 75 years. 1 However, most guidelines recommend high-intensity statin therapy for … WebPurpose of review: In randomized trials and many observational studies, statins are associated with a modest excess of type 2 diabetes mellitus. High-intensity statins, such as atorvastatin 80 mg and rosuvastatin 20 mg, are associated with a higher excess risk of diabetes than moderate-intensity statins, such as atorvastatin 10 mg, simvastatin 20-40 …
Statins and diabetes risk: how real is it and what are the ... - PubMed
WebThe guideline divides statin therapies into three intensity categories, based on how much LDL cholesterol is lowered with a daily dose: High intensity lowers LDL by at least 50%. It is generally prescribed to people with a history of cardiovascular disease or whose LDL level is higher than 190 mg/dL. Medium intensity lowers it from 30% to 49%. WebA high-intensity statin, defined as the dose at which a reduction in LDL-cholesterol of greater than 40% is achieved, is recommended as first-line therapy in all patients with familial hypercholesterolaemia. The dose of the statin should be titrated to achieve a reduction in LDL-cholesterol concentration of greater than 50% from baseline. north east news a1 crash
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Web30 de jun. de 2024 · Prompt initiation of high-intensity statin therapy is strongly recommended for every patient after an AMI – regardless of baseline LDL-cholesterol levels, – within 1-4 days of the index event[1]. The type and dose chosen should achieve LDL-C values of <55mg/dL (<1.4 mmol/L) AND a reduction of at least 50%. Web8 de mai. de 2012 · The SPARCL study reliably showed that high-dose atorvastatin at 80 mg/day reduces the risk of recurrent stroke and other cardiovascular events in patients … WebNote: The shading reflects doses listed in the ACC/AHA Guideline on Treatment of Blood Cholesterol (2013) as reflecting high-intensity therapy (≥ 50% reduction in LDL-C, … north east new build