Global lipids genetics consortium results
http://lipidgenetics.org/ WebAug 8, 2024 · Lipid levels are a major risk factor for cardiovascular disease, the leading cause of death in the United States . While lipid levels are known to have a highly …
Global lipids genetics consortium results
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WebApr 22, 2024 · Variants were robustly associated with LDL-C in a meta-analysis of genome-wide association studies (GWAS) involving 188,578 individuals primarily (96%) of European ancestry in the Global Lipids Genetic Consortium (GLGC) . As previously described by Ference et al., SNPs were iteratively selected for inclusion in order of decreasing … http://csg.sph.umich.edu/willer/public/lipids2024EastAsian/
http://csg.sph.umich.edu/willer/public/glgc-lipids2024/#:~:text=The%20Global%20Lipids%20Genetics%20Consortium%20aggregated%20GWAS%20results,N%3D48.1k%2C%202.9%25%29%2C%20and%20South%20Asian%20%28SAS%2C%20N%3D41.0k%2C%202.5%25%29. WebWe then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta ...
WebJul 14, 2016 · Given that several studies suggest an interdependence of cholesterol and vitamin D pathways in the pathogenesis of CAD, 55 we queried the association of rs12785878, in the largest publically available GWAS consortium results for lipids, the Global Lipids Genetics Consortium, 37 and found that this SNP was associated with a … WebMar 29, 2024 · Shown are the multivariable MR (MVMR) results from the discovery analysis, using genetic instruments for plasma TG levels from Global Lipids Genetics Consortium (GLGC) and disease traits from UKB. Levels of statistical significance are categorized into three tiers: Tier 1 (BB): At least Bonferroni-significant in both the …
WebThe GLGC (Global Lipids Genetics Consortium) focused on the genetic etiology of quantitative lipid traits ... and field center data for generating results and alert reports for participants. Field center staff may either record data and validate them directly in the system or collect data first on paper forms and then key and validate them into ...
WebMar 21, 2024 · The latest GWAS from the Global Lipids Genetics Consortium (GLGC) reports 941 loci, ... This inequity results from a variety of reasons linked to historical national developments, scientific and ... phone number for 5th 3rd bank 800 numberWebDec 8, 2024 · In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood … phone number for 23 and me customer supportWebAug 17, 2024 · In some, but not all observational studies, higher TSH and lower FT4 are associated with unhealthier lipids and glucose metabolism, such as an association of higher TSH with higher total ... how do you pronounce newselaWebMar 2, 2024 · The Global Lipids Genetics Consortium (GLGC) study is a genome-wide genotyping analysis of 188,577 individuals to search for loci associated with plasma lipid levels . The aim of the FinnGen study is to research the national health registry data and genome of 500,000 Finns. phone number for 6yaWebNov 26, 2013 · Global Lipids Genetics Consortium Results. Reference. Willer CJ et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 2013. … phone number for 4patriotsWebMar 11, 2024 · Leveraging data from the Global Lipids Genetics Consortium (n = 173 082), we identified genetic variants to proxy LDL-c levels generally, ... (n = 1 012 240) using Mendelian randomization, and replicated results using the outcome of longevity to the 90th vs. 60th percentile age (11 262 cases/25 483 controls). Results. how do you pronounce neuschwansteinWebMar 23, 2024 · We defined novel SNPs as those associated with the trait of interest at P < 5 × 10 −8 in our analyses in which an association had not been previously reported at P < 5 × 10 −8, within 1 MB and at r 2 < 0.001, by the Global Lipids Genetics Consortium (for LDL cholesterol, triglycerides, and HDL cholesterol) or by Kettunen and colleagues ... phone number for 7 on your side washington dc