WebJan 23, 2024 · CTR1 inhibition results in a mild reduction in available copper, and ATP7A knockdown results in copper accumulation in the cells (Table 1). Disruption … WebMay 8, 2015 · CTR1 is a negative regulator of the ethylene pathway, loss-of-function mutations in CTR1 resulting in constitutive ethylene responses, with phosphorylation of …
Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes
WebJan 23, 2024 · Unexpectedly, the nuclear-localized CTR1 enhances ethylene responses through a mechanism that does not require its kinase activity. This inhibits the fast recovery of seedling growth back to... WebJan 1, 2024 · Ctr1 modulates AAV-induced α-syn pathology in the nigrostriatal system. These in vitro findings suggest that α-syn pathology can be regulated by Ctr1. Given that … sid crosby hockey player
Hair Cell Protection from Ototoxic Drugs - researchgate.net
WebNov 6, 2012 · CTR1 consists of a unique N-terminal regulatory domain and a C-terminal serine/threonine kinase domain ( Fig. 1 A ). Because CTR1 is most similar in sequence … WebNov 9, 2015 · Cisplatin-induced ototoxicity and cochlear uptake can be modulated by administration of a CTR1 inhibitor, copper sulfate, and the possibility of local administration of CTR1 inhibitors during cisplatin therapy as a … WebThe possibility of local administration of CTR1 inhibitors during cisplatin therapy as a means of otoprotection is thereby raised. AB - The goal of this study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by cisplatin, a potent anticancer platinum analog used in the treatment of a variety of solid ... sid crowe cleveland ga