WebNov 15, 2024 · Chromatin assembly factor-1 (CAF-1) is a highly conserved histone chaperone heterotrimer, which consists of p48, p60 and p150 (CHAF1A) subunits. CAF-1 plays an essential role in diverse biological processes, such as DNA replication during the nucleosome formation and the chromatin restoration after DNA repair [ 11 , 12 , 13 , 14 , … WebMar 9, 2024 · GSEA (gene set enrichment analysis) GSEA (Mootha et al., 2003; Subramanian et al., 2005) is a bioinformatic software that analyze and determine the statistically significant and concordant differences between two datasets based on a priori defined set of genes.The enrichment of CHAF1A co-expression genes were used to …
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WebMar 5, 2024 · CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via … WebUseful information about the protein provided by UniProt. Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones ... famous tik tok emu
(PDF) Histone Chaperones and Digestive Cancer: A Review
WebApr 12, 2024 · We then obtained methylation models containing 10 genes by univariate and multifactorial COX analysis. High risk genes with HR > 1 include IQGAP3, PTBP1, STAC3, CUX1, SLC2A1, and CA2, and low risk genes with HR < 1 include IGBP1, DUOX1, CHAF1A, and STAC3. We verified the accuracy of the model from inside TCGA and … WebMar 30, 2024 · CHAF1A (CAF p150), the main functional subunit of CAF-1, promotes rapid assembly of nucleosomes on newly replicated DNA, and involved in DNA replication, … WebJul 1, 2016 · However, CHAF1A expression and its role in hepatocellular carcinoma (HCC) remain poorly characterized. In this study, we first investigated CHAF1A expression in … famous salt lake